What is the antidote for digoxin toxicity?

What is the antidote for digoxin toxicity?

• A. Digibind
• B. Protamine sulfate
• C. Vitamin K
• D. Naloxone

Answer: (A)

Digoxin toxicity is reversed by digoxin-specific antibody fragments, such as Digibind (DigiFab). These antibodies bind free digoxin in the bloodstream with high affinity, neutralizing its effects on the Na+/K+ ATPase in heart tissue and allowing the drug to be cleared. This rapid neutralization can quickly improve dangerous arrhythmias and hyperkalemia associated with digoxin poisoning. The other agents listed target different toxins or conditions (for example, protamine reverses heparin, vitamin K reverses warfarin, and naloxone reverses opioid overdose), so they do not address digoxin poisoning.

Digoxin toxicity is reversed by digoxin-specific antibody fragments, such as Digibind (DigiFab). These antibodies bind free digoxin in the bloodstream with high affinity, neutralizing its effects on the Na+/K+ ATPase in heart tissue and allowing the drug to be cleared. This rapid neutralization can quickly improve dangerous arrhythmias and hyperkalemia associated with digoxin poisoning. The other agents listed target different toxins or conditions (for example, protamine reverses heparin, vitamin K reverses warfarin, and naloxone reverses opioid overdose), so they do not address digoxin poisoning.