Tx for heparin-induced bleeding?

Tx for heparin-induced bleeding?

• A. Stop heparin
• B. Volume replacement
• C. Platelet transfusion
• D. Protamine

Answer: (D)

Protamine sulfate directly neutralizes unfractionated heparin, stopping the anticoagulant effect that’s driving the bleeding. It binds heparin to form a stable complex, effectively reversing its action and allowing normal clotting to resume. Stopping the heparin infusion and providing supportive care may help, but they don’t rapidly reverse the anticoagulation. Platelet transfusion isn’t indicated for reversing heparin—it's used for platelet problems or HIT, not as the antidote. Protamine is the treatment of choice because it targets the underlying cause of the bleeding by counteracting the heparin itself.

Protamine sulfate directly neutralizes unfractionated heparin, stopping the anticoagulant effect that’s driving the bleeding. It binds heparin to form a stable complex, effectively reversing its action and allowing normal clotting to resume. Stopping the heparin infusion and providing supportive care may help, but they don’t rapidly reverse the anticoagulation. Platelet transfusion isn’t indicated for reversing heparin—it's used for platelet problems or HIT, not as the antidote. Protamine is the treatment of choice because it targets the underlying cause of the bleeding by counteracting the heparin itself.