Deficiency in factor VIII is associated with which bleeding disorder?

Deficiency in factor VIII is associated with which bleeding disorder?

• A. Hemophilia B
• B. Hemophilia A
• C. Von Willebrand disease
• D. Sickle cell disease

Answer: (B)

Deficiency of factor VIII disrupts the intrinsic pathway of coagulation, reducing thrombin generation because factor VIII acts as a cofactor for activated factor IX in the tenase complex. This leads to impaired clot formation and a tendency for deep tissue and joint bleeding. Clinically, this condition is Hemophilia A, an X-linked recessive disorder that is classically associated with prolonged bleeding after injuries or surgeries and hemarthroses. Hemophilia B is due to factor IX deficiency, not factor VIII. Von Willebrand disease involves a deficiency or dysfunction of von Willebrand factor, which affects platelet adhesion and also lowers factor VIII stability, but it is not a direct factor VIII deficiency. Sickle cell disease is a hemoglobinopathy with vaso-occlusive complications and does not arise from a deficiency in a coagulation factor.

Deficiency of factor VIII disrupts the intrinsic pathway of coagulation, reducing thrombin generation because factor VIII acts as a cofactor for activated factor IX in the tenase complex. This leads to impaired clot formation and a tendency for deep tissue and joint bleeding. Clinically, this condition is Hemophilia A, an X-linked recessive disorder that is classically associated with prolonged bleeding after injuries or surgeries and hemarthroses.

Hemophilia B is due to factor IX deficiency, not factor VIII. Von Willebrand disease involves a deficiency or dysfunction of von Willebrand factor, which affects platelet adhesion and also lowers factor VIII stability, but it is not a direct factor VIII deficiency. Sickle cell disease is a hemoglobinopathy with vaso-occlusive complications and does not arise from a deficiency in a coagulation factor.