Among HIV-associated neoplasms, which is most common?

Among HIV-associated neoplasms, which is most common?

• A. Kaposi sarcoma
• B. Cervical cancer
• C. Lung cancer
• D. Non-Hodgkin lymphoma

Answer: (D)

HIV-related cancers rise as the immune system fails to keep oncogenic viruses in check, so cancers linked to those viruses become more common. Non-Hodgkin lymphoma is the most frequent HIV-associated cancer because EBV-driven B-cell proliferations flourish when T-cell surveillance is diminished. Kaposi sarcoma, tied to HHV-8, is also common in HIV, but its incidence has declined with effective antiretroviral therapy, while B-cell lymphomas remain more prevalent in many settings. Cervical cancer risk is increased in people with HIV due to HPV, but it is not the most common HIV-associated malignancy. So, among cancers seen with HIV, non-Hodgkin lymphoma tops the list.

HIV-related cancers rise as the immune system fails to keep oncogenic viruses in check, so cancers linked to those viruses become more common. Non-Hodgkin lymphoma is the most frequent HIV-associated cancer because EBV-driven B-cell proliferations flourish when T-cell surveillance is diminished. Kaposi sarcoma, tied to HHV-8, is also common in HIV, but its incidence has declined with effective antiretroviral therapy, while B-cell lymphomas remain more prevalent in many settings. Cervical cancer risk is increased in people with HIV due to HPV, but it is not the most common HIV-associated malignancy. So, among cancers seen with HIV, non-Hodgkin lymphoma tops the list.